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Toxic Reactions: Overview01:26

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
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Histology Basics and Cell Death Detection in Honeybee Tissue
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Multi-organ dysfunction following honeybee bite-A rare entity.

Satish Kumar Prasad1, Sameer Kumar Mehta2, Bhagyalakshmi Satyanarayan3

  • 1M.D. Medicine, Senior Consultant, Consultant, Tata Main Hospital, Jamshedpur, Jharkhand, India.

Journal of Family Medicine and Primary Care
|November 19, 2020
PubMed
Summary
This summary is machine-generated.

Honeybee bites can cause severe systemic toxic reactions, leading to multiorgan dysfunction. This case highlights rare complications including acute kidney injury, thrombocytopenia, and bradycardia following a single bee sting.

Keywords:
Bradycardiahoneybeemulti-organ dysfunctionthrombocytopenia

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Area of Science:

  • Toxicology
  • Allergology
  • Internal Medicine

Background:

  • Honeybee stings commonly cause localized allergic reactions.
  • Systemic toxic reactions and multiorgan dysfunction are rare but serious complications.
  • Reported severe outcomes include acute renal failure and Kounis syndrome (acute myocardial infarction).

Observation:

  • A case of severe systemic toxicity following a honeybee bite is presented.
  • The patient experienced a localized allergic reaction and pain.
  • Multiorgan dysfunction developed, including acute kidney injury, thrombocytopenia, bradycardia, keratitis, and abnormal liver function tests.

Findings:

  • The case demonstrates a rare instance of multiorgan dysfunction after a honeybee bite.
  • Specific complications observed were acute kidney injury, thrombocytopenia, bradycardia, keratitis, and deranged liver function.
  • This underscores the potential for severe systemic effects beyond typical allergic responses.

Implications:

  • Clinicians should be aware of the potential for severe systemic toxicity and multiorgan dysfunction following honeybee stings.
  • Prompt recognition and management of these rare complications are crucial for patient outcomes.
  • Further research into the mechanisms of severe honeybee venom toxicity is warranted.