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MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
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RNA virus-encoded microRNAs: biogenesis, functions and perspectives on application
Shoubin Zhan1, Yanbo Wang1, Xi Chen1
1Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023 China.
Exrna
|November 19, 2020
Summary
RNA virus-encoded microRNAs (miRNAs) are increasingly discovered, yet their functions remain unclear. This review explores their biogenesis, roles in virus-host interactions, and potential for diagnosing and treating viral diseases.
Area of Science:
- Molecular Biology
- Virology
- Genetics
Background:
- MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression posttranscriptionally.
- miRNAs are vital in development and disease, expanding understanding of genome regulation.
- Hundreds of virus-encoded miRNAs exist, predominantly from DNA viruses.
Purpose of the Study:
- To review the biogenesis and functions of RNA virus-encoded miRNAs.
- To explore their roles in virus-host interactions.
- To highlight their diagnostic and therapeutic potential in viral diseases.
Main Methods:
- Literature review of studies on RNA virus-encoded miRNAs.
- Analysis of miRNA biogenesis pathways.
- Examination of functional roles in viral infections and host responses.
Main Results:
- The number of identified RNA virus-derived miRNAs is growing.
- Knowledge regarding their physiological and pathological roles is limited.
- Proposed roles in virus-host interactions are emerging.
Conclusions:
- RNA virus-encoded miRNAs represent a significant area for research.
- Understanding their functions is crucial for deciphering viral pathogenesis.
- These miRNAs hold promise for novel diagnostic and therapeutic strategies against viral diseases.
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