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INSM1 Expression in Angiosarcoma.

Laura M Warmke¹, Emma Grace Tinkham¹, Davis R Ingram²

¹Departments of Pathology.

American Journal of Clinical Pathology

|November 19, 2020

Summary

This summary is machine-generated.

Insulinoma-associated protein 1 (INSM1) is aberrantly expressed in some angiosarcomas, aiding in diagnosis. Rare INSM1 expression also occurs in desmoplastic small round cell tumors and synovial sarcomas.

Keywords:

Angiosarcoma INSM1 Immunohistochemistry Neuroendocrine differentiation Vascular markers

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Area of Science:

Oncology
Pathology
Molecular Diagnostics

Background:

Neuroendocrine markers can be aberrantly expressed in sarcomas, leading to diagnostic challenges.
Insulinoma-associated protein 1 (INSM1) is a recognized marker for neuroendocrine differentiation.

Purpose of the Study:

To investigate the expression of INSM1 in angiosarcomas and other sarcoma subtypes.
To assess the utility of INSM1 as a diagnostic marker in sarcomas.

Main Methods:

Tissue microarrays of various sarcomas, including angiosarcoma, were analyzed for INSM1 expression.
Immunoreactivity for INSM1 was quantified by the percentage of positive tumor cell nuclei and staining intensity.

Main Results:

INSM1 expression was detected in 26% of angiosarcomas, often with strong and diffuse labeling.
Rare INSM1 expression was observed in desmoplastic small round cell tumors (11%) and synovial sarcomas (4%).
No INSM1 expression was found in Ewing sarcoma, clear cell sarcoma, leiomyosarcoma, alveolar soft part sarcoma, epithelioid sarcoma, or undifferentiated pleomorphic sarcoma.

Conclusions:

Aberrant INSM1 expression occurs in a subset of angiosarcomas, potentially assisting in their diagnosis.
Desmoplastic small round cell tumors and synovial sarcomas can rarely show focal INSM1 expression, mimicking neuroendocrine features.