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Related Experiment Video

Updated: Nov 29, 2025

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Published on: November 23, 2019

Clinically Important Differences for Mobility Measures Derived from the Testosterone Trials.

Alisa J Stephens-Shields¹, John T Farrar¹, Susan S Ellenberg¹

¹Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Journal of the American Geriatrics Society

|November 19, 2020

Summary

This summary is machine-generated.

Clinically important difference (CID) estimates for walking ability in older men with mobility limitations suggest meaningful improvements range from 16-30m for the 6-minute walk test and 5-15 points for the physical function test.

Keywords:

clinically important difference mobility improvement randomized controlled trials

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Area of Science:

Gerontology
Clinical Trials
Physical Therapy

Background:

Clinically important difference (CID) estimates are crucial for interpreting treatment effects on physical function.
Existing CID estimates vary across different patient populations.
This study focused on mobility-limited older men.

Purpose of the Study:

To determine the clinically important difference (CID) for two common measures of walking ability.
To provide meaningful benchmarks for physical function improvements in older men with mobility limitations.

Main Methods:

Longitudinal, multisite placebo-controlled trial.
Included 429 men with self-reported mobility limitation and gait speed < 1.2 m/s.
Combined testosterone- and placebo-allocated participants for analysis.

Main Results:

Mean changes in 6-minute walk distance (6MWD) and physical function (PF10) were analyzed based on self-reported mobility changes.
CID estimates for 6MWD ranged from 5.0-29.6 meters.
CID estimates for PF10 ranged from 5.0-15.2 points.

Conclusions:

CID estimates are influenced by the study population and measurement methods.
Increases of 16-30m for 6MWD and 5-15 points for PF10 over 12 months are clinically meaningful for this group.
These CID estimates can inform the design of future efficacy trials for physical function therapies.