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Cardiac injury is associated with inflammation in geriatric COVID-19 patients

Xu Yan1,2,3, Shuang Wang1,2,3, Piyong Ma4

  • 1Cardiology Department, China-Japan Union Hospital of Jilin University, Changchun, China.

Journal of Clinical Laboratory Analysis
|November 19, 2020
PubMed

Insights

Elderly patients with COVID-19 are susceptible to cardiac injury. Age and inflammation markers like procalcitonin and interleukin-6 significantly predict cardiac injury in this population.

Area of Science:

  • Cardiology
  • Geriatrics
  • Infectious Diseases
  • Immunology

Background:

  • Geriatric patients with COVID-19 face a high risk of cardiac injury.
  • Identifying factors influencing cardiac injury is crucial for heart protection in elderly patients.

Purpose of the Study:

  • To identify clinical and laboratory factors associated with cardiac injury in geriatric COVID-19 patients.
  • To determine the influence of these factors on cardiac injury through logistic regression.

Main Methods:

  • Analysis of clinical characteristics and laboratory results from 180 COVID-19 inpatients aged over 60.
  • Statistical analysis of correlations between cardiac injury and variables.
  • Multivariate logistic regression to assess predictive ability of variables.

Main Results:

  • Age significantly correlated with cardiac injury (p < 0.001).
  • Elevated inflammatory markers (procalcitonin, IL-2 receptor, IL-6, IL-10, TNF-α, hs-CRP), D-dimer, white blood cells, neutrophils, and decreased lymphocytes and NK cells were associated with cardiac injury.
  • These factors demonstrated predictive ability in logistic regression.

Conclusions:

  • Age and inflammatory factors significantly influence cardiac injury in elderly COVID-19 patients.
  • Targeting inflammation may offer cardiac protection in this vulnerable group.
Abstract

Keywords:
COVID-19cardiac injuryelderly patientinflammationtroponin

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