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Published on: November 10, 2023
COVID-19: Current Understanding of Pathophysiology
Gentle Sunder Shrestha1, Sushil Khanal2, Sachit Sharma1
1Department of Anaesthesiology, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
This review explores the pathophysiology of COVID-19, detailing how SARS-CoV-2 affects multiple organ systems beyond the respiratory tract. Understanding this multi-organ involvement is crucial for managing coronavirus disease 2019 and guiding future research.
Area of Science:
- Pathophysiology
- Infectious Diseases
- Pulmonology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
- SARS-CoV-2 utilizes Angiotensin-Converting Enzyme 2 receptors for cellular entry.
- While respiratory involvement is common, other systems are frequently affected.
Purpose of the Study:
- To review the pathophysiological basis of organ system involvement in COVID-19.
- To enhance understanding for improved patient management.
- To guide future clinical trial design.
Main Methods:
- Literature review of articles from various databases.
- Assembly of current evidence on COVID-19 pathophysiology.
- Focus on multi-organ system effects.
Main Results:
- COVID-19 pathophysiology involves multi-organ system damage.
- Understanding ACE2 receptor interaction is key.
- Extrapulmonary manifestations are significant.
Conclusions:
- Comprehensive understanding of COVID-19 pathophysiology aids patient care.
- Knowledge of multi-system effects is vital for effective treatment strategies.
- This review provides a foundation for future research and clinical trials.
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