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COVID-19 pneumonia causes lower testosterone levels.

Sezgin Okçelik1

  • 1Urology Department, Nevşehir State Hospital, Nevşehir, Turkey.

Andrologia
|November 19, 2020
PubMed
Summary

COVID-19 infection may cause testicular damage, indicated by decreased testosterone levels, particularly in patients with viral pneumonia. Further research is needed to understand the long-term effects of COVID-19 on male reproductive health.

Keywords:
COVID-19FSHLHTotal testosteronepneumonia

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Area of Science:

  • Endocrinology
  • Virology
  • Reproductive Health

Background:

  • The COVID-19 pandemic has raised concerns about potential long-term health consequences, including effects on male reproductive function.
  • Previous studies have suggested a possible link between viral infections and testicular damage, but specific data on COVID-19 is limited.

Purpose of the Study:

  • To investigate the impact of COVID-19 infection on testicular function in adult males.
  • To assess potential changes in key reproductive hormones such as testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in relation to COVID-19 status and pneumonia.

Main Methods:

  • A prospective study evaluated 44 male patients attending a COVID-19 outpatient clinic.
  • Data collected included patient demographics, COVID-19 PCR results, presence of pneumonia, and serum levels of total testosterone, LH, and FSH.
  • Statistical analyses were performed to compare hormonal levels between COVID-19 positive and negative groups, and between patients with and without pneumonia.

Main Results:

  • No significant differences in FSH, LH, and testosterone were observed between COVID-19 PCR positive and negative patients overall.
  • However, luteinizing hormone (LH) levels were found to be statistically significantly higher in the COVID-19 PCR positive group.
  • Testosterone levels were significantly lower in patients diagnosed with COVID-19 pneumonia compared to those without pneumonia.

Conclusions:

  • Acute COVID-19 infection may lead to a decrease in testosterone levels, especially in patients with viral pneumonia.
  • While overall hormone levels may not differ significantly between infected and non-infected individuals, specific hormonal changes like elevated LH in positive cases warrant further investigation.
  • The findings suggest a potential for testicular damage associated with COVID-19, particularly in severe cases involving pneumonia.