Related Experiment Video

Updated: Nov 29, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.0K

[Covid-19 and diabetes]

N Paquot1, R P Radermecker1

  • 1Liège Université, Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Liège, Belgique.

Revue Medicale De Liege
|November 19, 2020
PubMed

Insights

Diabetes significantly increases the risk of severe COVID-19 outcomes. Early insulin therapy is suggested for type 2 diabetes patients hospitalized with COVID-19, but further research is needed.

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Critical Care Medicine

Background:

  • Diabetes mellitus is a critical comorbidity associated with severe outcomes in SARS-CoV-2 infections.
  • Diabetic patients exhibit a 2-3 fold higher hospitalization rate in ICUs for COVID-19 and a 3-4 fold increased risk of critical or fatal disease progression.
  • Mechanisms linking diabetes to severe COVID-19 include hyperglycemia, immune dysfunction, obesity, and hypertension.

Purpose of the Study:

  • To review the link between diabetes and severe COVID-19.
  • To discuss the challenges and potential strategies for managing diabetes in COVID-19 patients.
  • To highlight the need for further research on optimal antidiabetic treatment.

Main Methods:

  • Literature review and synthesis of existing data on diabetes and COVID-19.
  • Analysis of epidemiological data and proposed pathophysiological mechanisms.
  • Discussion of clinical management recommendations and future research directions.

Main Results:

  • Diabetes is a major risk factor for severe COVID-19, critical illness, and mortality.
  • Multiple diabetes-related and associated factors contribute to increased COVID-19 severity.
  • Optimizing glycemic control is crucial but challenging; early insulin introduction is recommended for hospitalized type 2 diabetes patients.

Conclusions:

  • Diabetes significantly elevates the risk of severe COVID-19.
  • Effective management strategies, including glycemic control and appropriate antidiabetic treatments, are essential for improving outcomes.
  • Further research is imperative to establish optimal treatment protocols and enhance prognosis for high-risk diabetic patients with COVID-19.

Keywords:
Glucose controlHbA1cInsulinMortalitySars2CoVObesity

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

548
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.1K

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
203
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.7K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.9K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.6K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.7K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.5K