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BRENDA, the ELIXIR core data resource in 2021: new developments and updates.

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This summary is machine-generated.

The BRENDA enzyme database is a comprehensive resource for functional enzyme and metabolism data, offering millions of manually curated entries and advanced search functionalities for researchers worldwide.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Enzymology

Background:

  • The BRENDA enzyme database has served as a primary repository for functional enzyme and metabolism data since 1987.
  • It was recognized as an ELIXIR Core Data Resource in 2018, highlighting its significance.
  • The database continuously curates and updates enzyme information, integrating newly discovered enzymes.

Purpose of the Study:

  • To provide a comprehensive and accessible resource for enzyme and metabolism data.
  • To enhance data retrieval and visualization tools for users.
  • To integrate new features for enzyme discovery and analysis.

Main Methods:

  • Manual data extraction from primary literature, text and data mining, data integration, and prediction algorithms.
  • Continuous curation and updates of classified and newly discovered enzymes.
  • Development of advanced search functionalities, interactive pathway maps, and a new 3D protein structure viewer.

Main Results:

  • BRENDA contains over 5 million data entries for approximately 90,000 enzymes from 13,000 organisms.
  • Includes supplementary data such as disease information, protein sequences, 3D structures, and kinetic data.
  • Introduced enhanced usability features including revised Pathway Maps, an improved Enzyme Summary Page, and a new 3D viewer.

Conclusions:

  • BRENDA remains a vital, continuously updated resource for enzyme and metabolism research.
  • New features enhance usability and provide advanced tools for enzyme data exploration and discovery.
  • The integration of EnzymeDetector facilitates the identification of both eukaryotic and prokaryotic enzymes.