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Updated: Nov 29, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Selectively Oxidative C(sp2)-H/C(sp3)-H Cross-Coupling of Benzamides with Amides by Nickel Catalysis
Ningning Lv1, Shuling Yu2, Chao Hong2
1College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Abstract:
The oxidative cross-coupling between the α-C(sp3)-H bond of amide in DMAc and the inert ortho-C(sp2)-H bond of benzamides is achieved for the first time by nickel catalysis, with the assistance of 8-aminoquinolyl group in the presence of a silver oxidant. Notably, the selectivity of conversion can be perfectly controlled by modulating the oxidant additives, and the products from the coupling of the C(sp3)-H bond adjacent to nitrogen of amides with benzamides are approached through the use of peroxide.
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