Cytotoxic ergostane-type steroids from Ganoderma lingzhi
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Updated: Nov 29, 2025

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
Jin-Hai Yu1, Shu-Juan Yu1, Kai-Lu Liu1
1School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
Abstract:
Two new ergostane-type steroids (1 and 2) have been isolated from the fruiting body of a medicinal macro fungus Ganoderma lingzhi. The structures including the absolute configurations of them were elucidated by a combination of different spectroscopic analyses especially 13C NMR and ECD calculations. Compound 2 features an unusual 1,2-dioxolane moiety. Our bioassays revealed that the two steroids showed remarkable cytotoxicity against human A549 (lung) and MCF-7 (breast) tumor cell lines, with IC50 values ranging from 5.15 to 8.57 μg/mL.
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