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Endocrine-disrupting effects of bisphenols on urological cancers

Eve Pellerin1, Christophe Caneparo2, Stéphane Chabaud2

  • 1Centre de Recherche en Organogénèse Expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, Québec, Canada; Intersectorial Centre for Endocrine Disruptors Analysis, Institut National de La Recherche Scientifique (INRS), Québec, Canada; ARThrite Research Center, Laval University, Québec, Canada.

Environmental Research
|November 19, 2020
PubMed

Insights

Bisphenols, common endocrine-disrupting chemicals, may contribute to prostate and bladder cancer development. Understanding their mechanisms is crucial for public health.

Area of Science:

  • Endocrinology
  • Toxicology
  • Urology

Background:

  • Bisphenols are endocrine-disrupting chemicals (EDCs) prevalent in consumer products.
  • They interfere with hormonal signaling, affecting tissues like the prostate and bladder.
  • Exposure to bisphenols has been linked to cancer progression and metastasis.

Purpose of the Study:

  • To review the role of bisphenols in the development of prostate and bladder cancers.
  • To explore the mechanisms of bisphenol-induced cell toxicity in urological malignancies.
  • To assess the public health implications of widespread bisphenol exposure.

Main Methods:

  • Literature review focusing on endocrine-disrupting chemicals and urological cancers.
  • Analysis of studies investigating bisphenol mechanisms of action.
  • Synthesis of evidence linking bisphenol exposure to prostate and bladder carcinogenesis.

Main Results:

  • Bisphenols can bind to estrogen and androgen receptors, potentially altering prostate and bladder homeostasis.
  • Evidence suggests a link between EDC exposure and the development of prostate cancer.
  • Bisphenols may impact bladder physiology and cancer development despite it not being a classical hormone-sensitive tissue.

Conclusions:

  • Bisphenols play a potential role in the development of prostate and bladder cancers.
  • Further research into the mechanisms of bisphenol toxicity is warranted.
  • Understanding these roles is vital for public health strategies concerning EDC exposure.
Keywords:
BisphenolBladderCancerEndocrine disruptorProstate

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