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An acceptability study of two pivampicillin mixtures in children in general practice
Insights
Children
Area of Science:
- Pediatric medicine
- Pharmacology
- Infectious diseases
Background:
- Antibiotic adherence is crucial for treating pediatric respiratory infections.
- Flavor additives can influence medication acceptability in children.
Purpose of the Study:
- To compare paediatric patient compliance with pivampicillin mixtures containing different flavor additives.
- To assess the impact of flavor on taste acceptability and ease of administration.
Main Methods:
- 84 children with respiratory infections were randomized to receive pivampicillin (Pondocillin) with either cocoa-peppermint or banana flavoring.
- Taste acceptability and ease of administration were scored at the beginning and end of treatment.
Main Results:
- Pivampicillin with cocoa-peppermint flavor showed a significant decrease in taste acceptability (p=0.046) and ease of administration (p=0.049).
- Pivampicillin with banana flavor exhibited only minor, non-significant changes in these parameters.
Conclusions:
- Banana flavoring may improve paediatric patient compliance with pivampicillin treatment compared to cocoa-peppermint.
- Flavor choice is an important consideration for optimizing antibiotic adherence in pediatric populations.
Abstract:
In order to evaluate the paediatric patient compliance to treatment with penicillin mixture, 84 children with respiratory system infections were randomized to treatment with pivampicillin (Pondocillin) mixture with two different flavour additives, cocoa-peppermint and banana. Using a scoring system, the taste acceptability and the easiness of administration were evaluated at the beginning and the end of treatment. While taste acceptability and easiness of administration decreased significantly during the treatment (p = 0.046 for taste and p = 0.049 for easiness) with Pondocillin cocoa-peppermint mixture, only small non-significant differences were noticed during treatment with Pondocillin banana mixture.