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Heart Failure in Diabetes Mellitus: An Updated Review

Catrin Sohrabi1, Bunny Saberwal2, Wei-Yao Lim2

  • 1Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Current Pharmaceutical Design
|November 20, 2020
PubMed

Insights

Diabetes mellitus and heart failure remain serious global health issues. This review examines glucose-lowering drugs

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetes mellitus (DM) and heart failure (HF) are prevalent comorbidities
  • These conditions contribute significantly to global morbidity and mortality rates.
  • Despite advancements, high mortality and hospitalization persist.

Purpose of the Study:

  • To review the impact of glucose-lowering therapies on heart failure outcomes in patients with diabetes.
  • To explore non-conventional management strategies for DM and HF.
  • To discuss potential therapeutic targets based on alternative pathophysiological mechanisms.

Main Methods:

  • Literature review of current glucose-lowering therapies.
  • Analysis of clinical outcomes related to heart failure.
  • Exploration of emerging pathophysiological insights.

Main Results:

  • Certain glucose-lowering therapies demonstrate varying effects on heart failure outcomes.
  • Intensive glycemic control alone has not fully mitigated HF risks.
  • Novel therapeutic pathways are under investigation.

Conclusions:

  • The choice of glucose-lowering therapy is critical for managing heart failure in diabetic patients.
  • Further research into novel mechanisms and treatments is warranted.
  • Integrated management strategies are essential for improving patient outcomes.

Keywords:
DMHFHeart failureT2DMdiabetesdiabetic cardiomyopathy

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