Therapeutic modalities and novel approaches in regenerative medicine for COVID-19

Area of Science:

• Virology
• Immunology
• Pharmacology

Background:

• The COVID-19 pandemic caused by SARS-CoV-2 has led to a global health crisis with significant socio-economic impacts.
• Extensive research is underway to develop effective treatments, including antivirals, vaccines, and monoclonal antibodies.
• Advanced therapeutic strategies, such as cell and gene editing, are also being explored for COVID-19 treatment.

Purpose of the Study:

• To review the pathogenesis of SARS-CoV-2.
• To discuss current and emerging therapeutic candidates for COVID-19.
• To highlight advanced therapeutic modalities under investigation.

Main Methods:

• Literature review of scientific articles and clinical trial data.
• Analysis of preclinical (in vitro/in vivo) and early-phase clinical study findings.
• Synthesis of information on SARS-CoV-2 mechanisms and therapeutic strategies.

Main Results:

• SARS-CoV-2 pathogenesis involves complex interactions with host cellular machinery.
• A range of therapeutic strategies are in development, showing promise in early studies.
• Cell- and gene-editing therapies represent a novel frontier in COVID-19 treatment research.

Conclusions:

• Understanding SARS-CoV-2 pathogenesis is crucial for developing targeted therapies.
• Multiple therapeutic avenues are being pursued, with ongoing evaluation needed.
• Advanced therapies hold potential but require further rigorous assessment.