Related Experiment Video
Updated: Nov 29, 2025
07:28
Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
Published on: November 19, 2012
15.5K
Endovascular Cerebral Venous Sinus Imaging with Optical Coherence Tomography
C R Pasarikovski1, J C Ku2, J Keith3
1From the Division of Neurosurgery (C.R.P., J.C.K.), Department of Surgery, University of Toronto, Toronto, Ontario, Canada chris.pasarikovski@mail.utoronto.ca.
AJNR. American Journal of Neuroradiology
|November 20, 2020
Summary
This study demonstrates the feasibility of using high-resolution optical coherence tomography for imaging cerebral venous sinuses in a preclinical model. This technique shows promise for diagnosing and understanding sinus-related diseases.
Area of Science:
- Neuroimaging
- Medical Devices
- Preclinical Research
Background:
- Cerebral venous sinus imaging has advanced significantly, with intravascular sonography aiding understanding of sinus thrombosis and intracranial hypertension.
- Optical coherence tomography (OCT) offers the highest resolution intravascular imaging but has not been applied to cerebral venous sinuses.
Purpose of the Study:
- To develop a preclinical animal model for endovascular OCT imaging of cerebral venous sinuses.
- To compare OCT findings with histological data in this model.
Main Methods:
- Four Yorkshire swine underwent catheterization of the superior sagittal sinus using a monorail technique.
- Intravascular OCT imaging was performed after luminal blood clearance, followed by sinus resection and histological comparison using Bland-Altman analysis.
Main Results:
- Successful OCT imaging was achieved in 3 of 4 swine, visualizing sinus lumen, dural arteries, and cortical veins.
- Average diameters measured were 3.14 mm (sinus), 135 µm (arteries), and 260 µm (veins).
- Good agreement was found between OCT and histological measurements.
Conclusions:
- Endovascular OCT imaging of cerebral venous sinuses is feasible in a preclinical setting.
- This technique has potential for diagnosing and understanding various sinus diseases.
- Further human safety and feasibility studies are warranted.
Related Concept Videos
01:19Imaging Studies VII: Vascular Imaging
146
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
146
01:27Imaging Studies III: Computed Tomography
149
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
149
01:10Computed Tomography
7.7K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.7K
01:28Imaging Studies for Cardiovascular System V: CT
154
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
154
01:21Imaging Studies for Cardiovascular System IV: CMRI
220
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
220
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
146
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
146