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Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Ryan S Roark1, Hui Li1, Wilton B Williams2,3

  • 1Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|November 20, 2020
PubMed
Summary

Rhesus macaques infected with simian-human immunodeficiency virus show HIV-1 envelope protein and antibody coevolution mirroring human responses. This macaque model aids in understanding broadly neutralizing antibody development for HIV-1 immunogen design.

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