Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Control Systems

Control Systems

Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Glasgow Coma Scale as a predictor of mortality in intensive care: relevance of underlying cause of impaired consciousness.

Journal of critical care·2026

Same author

Ablatio-bilica: safety of biliary intraductal radiofrequency ablation in patients with unresectable extrahepatic biliary tract cancer undergoing systemic anti-tumor therapy: a phase II, multi-center, randomized, and controlled study.

Frontiers in oncology·2026

Same author

Improving isobutanol and 2-ketoisovalerate production by reducing by-product synthesis in Klebsiella pneumoniae.

Enzyme and microbial technology·2026

Same author

Integrating synthetic biology and process engineering for enhanced isobutanol biosynthesis yield and sustainability.

Biotechnology for biofuels and bioproducts·2026

Same author

Engineering an AlkS-PalkB Transcription Factor-Based Biosensor With Improved Sensitivity to Isobutanol and Other Short-Chain Alcohols.

Microbial biotechnology·2025

Same author

Patterns of complementary and alternative medicine use in pediatric patients with inflammatory bowel disease.

Journal of pediatric gastroenterology and nutrition·2025

Same journal

Valorization of Agricultural Residues Through Nutrient Enrichment for Animal Farming.

Advances in biochemical engineering/biotechnology·2026

Same journal

Safety Aspects of Cell Culture-Derived Food for Human Consumption.

Advances in biochemical engineering/biotechnology·2026

Same journal

Correction to: Perspectives Towards AI and ML.

Advances in biochemical engineering/biotechnology·2026

Same journal

Valorization of Agricultural Residues for Biohydrogen Production via Dark Fermentation.

Advances in biochemical engineering/biotechnology·2026

Same journal

Composting of Agricultural Residues into Organic Fertilizers for Sustainable Agriculture.

Advances in biochemical engineering/biotechnology·2026

Same journal

Correction to: Theoretical Perspectives for Biomolecular Crystallization Prediction.

Advances in biochemical engineering/biotechnology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 29, 2025

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Published on: May 18, 2020

Digital Twins for Bioprocess Control Strategy Development and Realisation.

Christian Appl^1,2, André Moser¹, Frank Baganz²

¹Faculty of Medical and Life Sciences, Furtwangen University, Villingen-Schwenningen, Germany.

Advances in Biochemical Engineering/Biotechnology

|November 20, 2020

Summary

This summary is machine-generated.

Digital Twins offer a powerful method for modeling complex bioprocesses. These innovative tools accelerate the development and optimization of control strategies for bioprocess engineering and bioreactor operations.

Keywords:

Bioprocess Control strategy development Digital Twin Operator training simulator (OTS)

More Related Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Published on: September 28, 2018

Related Experiment Videos

Last Updated: Nov 29, 2025

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Published on: May 18, 2020

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Published on: September 28, 2018

Area of Science:

Bioprocess Engineering
Control Systems
Digital Twins

Background:

Complex bioprocesses involve intricate biological, chemical, and physical dynamics.
Developing effective control strategies is crucial for efficient bioprocess realization and optimization.
Traditional methods for control strategy development can be time-consuming and costly.

Purpose of the Study:

To outline the requirements for Digital Twins in bioprocess control strategy development.
To provide an overview of research utilizing Digital Twins for bioprocess control.
To explore the application of Digital Twins in academic education and operator training.

Main Methods:

Representing complex bioprocesses using Digital Twins, encompassing kinetics and physical characteristics.
Utilizing Digital Twins for the development and implementation of conventional and advanced control strategies.
Applying an early-stage Digital Twin for control strategy development in Saccharomyces cerevisiae fed-batch cultivation.

Main Results:

Digital Twins are identified as ideal tools for rapid and cost-effective control strategy development.
Research projects demonstrate the successful application of Digital Twins in bioprocess control.
A case study validates the use of an early-stage Digital Twin for optimizing fed-batch cultivation.

Conclusions:

Digital Twins are essential for the development, realization, and optimization of bioprocess control strategies.
These models enhance both the design of control systems and the training of personnel.
The integration of Digital Twins promises significant advancements in bioprocess engineering.