Related Experiment Video

Updated: Nov 29, 2025

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.0K

Diagnostic value of miRNA-122 in Kawasaki disease

H-F Lv1, X-Q Sun, H-X Zhou

  • 1Department of Pediatrics, Taizhou Jiangyan Hospital of Traditional Chinese Medicine, Taizhou, China. mlfsfm2@163.com.

European Review for Medical and Pharmacological Sciences
|November 20, 2020
PubMed

Insights

MicroRNA-122 (miRNA-122) levels are elevated in children with Kawasaki disease (KD), correlating with inflammation. This biomarker shows potential for diagnosing KD.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Molecular Diagnostics

Background:

  • Kawasaki disease (KD) is a critical pediatric illness.
  • Accurate diagnosis of KD is essential for timely treatment.
  • Biomarkers for KD diagnosis are actively sought.

Purpose of the Study:

  • To investigate the expression pattern of microRNA-122 (miRNA-122) in childhood Kawasaki disease.
  • To evaluate the diagnostic value of miRNA-122 in KD.

Main Methods:

  • Serum miRNA-122 levels were measured in 150 children with KD and 150 controls.
  • Correlations between miRNA-122 and clinical markers (CRP, NT-proBNP, sodium) were analyzed.
  • Receiver Operating Characteristic (ROC) curves assessed diagnostic accuracy.

Main Results:

  • Serum miRNA-122 levels were significantly higher in KD patients compared to controls.
  • miRNA-122 levels positively correlated with CRP and NT-proBNP, and negatively with sodium levels in acute KD.
  • The diagnostic performance for KD showed 78.67% specificity and 84.67% sensitivity (AUC=0.8861).

Conclusions:

  • Elevated serum miRNA-122 is characteristic of the acute phase of Kawasaki disease.
  • High miRNA-122 expression is linked to systemic inflammation in KD.
  • miRNA-122 holds promise as a diagnostic marker for Kawasaki disease.
Abstract

More Related Videos

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.5K
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.8K

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
102
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
119
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
263
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
158