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Is chronic obstructive pulmonary disease an independent predictor for adverse outcomes in coronavirus disease 2019

W-W Xiao1, J Xu, L Shi

  • 1Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China. yhy@zzu.edu.cn.

European Review for Medical and Pharmacological Sciences
|November 20, 2020
PubMed

Insights

Pre-existing chronic obstructive pulmonary disease (COPD) significantly increases the risk of adverse outcomes in patients with coronavirus disease 2019 (COVID-19). This meta-analysis confirms COPD as an independent predictor of poor prognosis in COVID-19 patients.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition.
  • Coronavirus disease 2019 (COVID-19) has emerged as a global health crisis.
  • The impact of pre-existing COPD on COVID-19 outcomes requires clarification.

Purpose of the Study:

  • To determine if chronic obstructive pulmonary disease (COPD) is an independent predictor of adverse outcomes in COVID-19 patients.
  • To synthesize existing evidence on the association between COPD and COVID-19 severity.
  • To provide insights for clinical risk stratification and management.

Main Methods:

  • A comprehensive literature search was conducted across major electronic databases (PubMed, Web of Science, EMBASE, CNKI).
  • Eligible studies reporting adjusted effect estimates were included.
  • A quantitative meta-analysis was performed using a random-effects model.

Main Results:

  • The meta-analysis included 18 studies encompassing 26,075 COVID-19 cases.
  • COPD was significantly associated with an increased risk of adverse outcomes (pooled effect = 1.53, 95% CI: 1.29-1.8).
  • The heterogeneity among studies was moderate (I2 = 35.4%).

Conclusions:

  • Pre-existing chronic obstructive pulmonary disease (COPD) is an independent risk factor for adverse outcomes in COVID-19 patients.
  • COPD presence necessitates careful monitoring and management in COVID-19 cases.
  • These findings underscore the importance of considering respiratory comorbidities in pandemic preparedness.
Abstract

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