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Nanogap-based all-electronic DNA sequencing devices using MoS2 monolayers.

A Perez1, Rodrigo G Amorim, Cesar E P Villegas

  • 1Instituto de Física Teórica, Universidade Estadual Paulista (UNESP), Rua Dr Bento T. Ferraz, 271, São Paulo, SP 01140-070, Brazil. alexandre.reily@unesp.br.

Physical Chemistry Chemical Physics : PCCP
|November 20, 2020
PubMed
Summary

Atom-thick molybdenum disulfide (MoS2) nanogaps show promise for electronic DNA sequencing. Simulations reveal the 1T

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biophysics

Background:

  • Nanopores in atom-thick materials offer a stable and scalable platform for single biomolecule electrical detection.
  • Molybdenum disulfide (MoS2) is a promising two-dimensional material for advanced electronic applications.

Purpose of the Study:

  • To theoretically investigate the potential of different phases of MoS2 nanogaps as all-electronic DNA sequencing devices.
  • To analyze the electronic transport properties of MoS2 nanogaps for DNA base selectivity.

Main Methods:

  • Density Functional Theory (DFT) simulations were employed to study the structural and energetic properties of MoS2 nanogaps.
  • Non-equilibrium Green's function (NEGF) formalism was used to simulate and analyze electronic transport across the nanogap devices.

Main Results:

  • The 1T'-MoS2 nanogap phase was found to be energetically more favorable than the 2H phase.
  • Distinct changes in conductance were observed for the 1T'-MoS2 device at zero bias, enabling DNA nucleobase selectivity.
  • The four DNA bases could be distinguished by analyzing conductance fluctuations near the Fermi level.

Conclusions:

  • 1T'-MoS2 nanogaps are a viable and energetically favorable candidate for all-electronic DNA sequencing.
  • The electronic transport properties of MoS2 nanogaps allow for the selective detection of individual DNA nucleobases.