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Metabolism, measurement and modelling: understanding and exploiting tissue oxygenation.

The Journal of physiology·2021

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High-Resolution Respirometry to Assess Bioenergetics in Cells and Tissues Using Chamber- and Plate-Based Respirometers

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How does oxygen diffuse from capillaries to tissue mitochondria? Barriers and pathways.

¹Department of Chemistry, New Mexico Institute of Mining and Technology (New Mexico Tech), Socorro, NM, USA.

The Journal of Physiology

|November 20, 2020

Summary

Oxygen transport to mitochondria is vital. Cellular lipids may accelerate oxygen diffusion through tissues, impacting tumor radiotherapy and tissue engineering.

Keywords:

hypoxia molecular dynamics simulation permeability radiotherapy tissue engineering

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Published on: February 8, 2017

Area of Science:

Biophysics
Cellular Physiology
Biochemistry

Background:

Efficient oxygen (O2) delivery to mitochondria is critical for cellular function.
Existing knowledge on oxygen diffusion pathways from capillaries to mitochondria is limited.
Cellular and extracellular structures influence subcellular oxygen availability.

Purpose of the Study:

To review the physiological and pathophysiological significance of oxygen availability.
To highlight computer modeling studies of oxygen transport at the cell membrane.
To explore alternative oxygen diffusion pathways within tissues.

Main Methods:

Review of existing experimental and computer modeling studies.
Analysis of oxygen transport mechanisms at the cellular level.
Investigation of lipid bilayer properties and their effect on oxygen solubility and diffusion.

Main Results:

Computer modeling suggests oxygen diffusion is accelerated in cellular lipids compared to aqueous fluids.
Enhanced oxygen solubility in lipid bilayers facilitates 'channelling'.
Anisotropic diffusion along lipid midplanes and lipid structure junctions promote rapid oxygen movement.

Conclusions:

Cellular lipids may play a significant role in accelerating oxygen transport within tissues.
Understanding these biophysical mechanisms is crucial for advancing tumor radiotherapy.
Knowledge of oxygen transport pathways can inform strategies in tissue engineering.