Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

361
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
361
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

64.4K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
64.4K
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

382
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
382
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

352
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
352
Psychological Responses to Stress01:20

Psychological Responses to Stress

358
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
358
Components of Stress01:23

Components of Stress

387
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
387

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain regions with gestational age differences mediate cognition in adolescents born very premature.

Communications biology·2026
Same author

Hypothalamus amyloid levels are associated with early sex-dependent alterations in energy homeostasis in TgF344-AD rats.

bioRxiv : the preprint server for biology·2026
Same author

Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes.

Proceedings of the National Academy of Sciences of the United States of America·2021
Same author

The effects of early life adversity on growth, maturation, and steroid hormones in male and female rats.

The European journal of neuroscience·2019

Related Experiment Video

Updated: Nov 29, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.1K

Modulating chronic stress.

Debra A Bangasser1, Evelyn Ordoñes Sanchez1

  • 1Department of Psychology and Neuroscience Program, Temple University, Philadelphia, United States.

Elife
|November 20, 2020
PubMed
Summary
This summary is machine-generated.

Social rank impacts how male and female mice react to chronic stress differently. This study explores sex-based variations in stress responses related to social hierarchy in mice.

Keywords:
chronic mild stressmouseneuroscienceprincipal component analysissex differencessocial behaviorsocial dominancestress

More Related Videos

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

23.0K
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

18.2K

Related Experiment Videos

Last Updated: Nov 29, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.1K
A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

23.0K
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

18.2K

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Endocrinology

Background:

  • Chronic stress significantly impacts health and behavior.
  • Social hierarchy is a known modulator of stress responses in various species.
  • Sex differences in stress-related disorders are well-documented.

Purpose of the Study:

  • To investigate the influence of social rank on chronic stress responses in male and female mice.
  • To determine if sex moderates the relationship between social status and stress resilience.

Main Methods:

  • Mice were assigned to different social ranks (dominant/subordinate).
  • Animals were subjected to a chronic unpredictable stress paradigm.
  • Behavioral tests (e.g., sucrose preference, open field) and physiological markers (e.g., corticosterone levels) were assessed.

Main Results:

  • Subordinate male mice exhibited heightened anxiety-like behaviors and depressive-like phenotypes compared to dominant males.
  • Female mice, regardless of social rank, showed less pronounced stress-induced behavioral changes than males.
  • Physiological stress markers indicated differential regulation between sexes and ranks.

Conclusions:

  • Social rank significantly modulates chronic stress responses in male mice, with subordinates being more vulnerable.
  • Female mice appear to exhibit greater resilience or a different pattern of response to chronic stress compared to males, irrespective of social status.
  • These findings highlight the complex interplay between social hierarchy, sex, and stress, with implications for understanding sex differences in stress-related disorders.