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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
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Statistically Defined Parkinson's Disease Executive and Memory Cognitive Phenotypes: Demographic, Behavioral, and
Samuel J Crowley1, Guita Banan2,3, Manish Amin2,3
1Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Journal of Parkinson'S Disease
|November 20, 2020
Summary
Parkinson's disease (PD) cognitive phenotypes exhibit distinct brain structural patterns. These findings highlight differing neuroanatomical underpinnings for executive and memory impairments in PD patients.
Area of Science:
- Neuroscience
- Neurology
- Cognitive Science
Background:
- Parkinson's disease (PD) presents with diverse cognitive deficits, including executive dysfunction, memory impairment, or minimal cognitive changes.
- Understanding these distinct cognitive profiles is crucial for targeted interventions.
Purpose of the Study:
- To statistically identify Parkinson's disease (PD) executive and memory cognitive phenotypes.
- To compare these PD phenotypes with non-PD individuals based on demographic, disease, vascular, and neuroimaging variables.
Main Methods:
- Utilized k-means cluster analysis on neuropsychological data from 116 non-demented PD patients and 62 controls.
- Assessed executive function, memory, gray/white matter integrity, and white matter connectivity using structural MRI and cognitive tests.
Main Results:
- Identified three PD cognitive phenotypes: PD Executive (n=25), PD Memory (n=35), and PD Cognitively Well (n=56).
- PD Executive group showed reduced subcortical gray matter, white matter, and fronto-striatal connectivity.
- PD Memory group exhibited reduced hippocampal-entorhinal connectivity; PD Cognitively Well showed minimal structural differences compared to controls.
Conclusions:
- Distinct PD cognitive phenotypes are associated with specific structural brain alterations in gray matter, white matter, and connectivity.
- These findings underscore the heterogeneous neuroanatomical basis of cognitive impairment in Parkinson's disease.
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