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Infusion Site Reactions: Classification in the Setting of Fosaprepitant Administration With Chemotherapy
Alexa N Segna1, Roberta H Baron1, Bevin Cohen1
1Memorial Sloan Kettering Cancer Center.
Clinical Journal of Oncology Nursing
|November 20, 2020
Summary
Few patients receiving fosaprepitant infusions experienced suspected extravasation. Of those with suspected events, a small percentage met the criteria for actual extravasation, indicating careful monitoring is key for infusion site adverse events (ISAEs).
Area of Science:
- Oncology
- Pharmacology
- Clinical Pharmacy
Background:
- Infusion site adverse events (ISAEs) are reported with fosaprepitant administration.
- Variability exists in the reported incidence and severity of ISAEs.
Purpose of the Study:
- To determine the incidence of suspected extravasation in cancer patients receiving fosaprepitant with chemotherapy.
- To assess if documented signs, symptoms, and management align with extravasation diagnostic criteria.
Main Methods:
- Retrospective review of electronic health records for patients receiving fosaprepitant infusions.
- Chart review of a sample of patients with suspected extravasation to verify diagnostic consistency.
Main Results:
- Approximately 3% of patients (460/15,667) had documented suspected extravasation.
- In a sample of 110 patients with suspected extravasation, only 6% (6/110) had documentation consistent with actual extravasation.
Conclusions:
- The incidence of documented suspected extravasation following fosaprepitant infusion is low.
- A small proportion of suspected extravasation cases meet diagnostic criteria, highlighting the importance of accurate documentation and assessment of ISAEs.
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