Related Experiment Video
Updated: Nov 29, 2025

An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
[Pericarditis is inflammation of the pericardium, which rheumatologists should know]
M Krusche1, U Schneider2, N Ruffer3
1Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. martin.krusche@charite.de.
Insights
Pericarditis, inflammation of the heart
Area of Science:
- Cardiology
- Rheumatology
- Immunology
Background:
- Pericarditis involves inflammation of the pericardium, potentially leading to pericardial effusion and myocardial involvement (perimyocarditis).
- It can occur with systemic rheumatic diseases or as a distinct entity.
- Idiopathic recurrent pericarditis (IRP) presents as relapsing pericarditis of unknown cause, sharing traits with autoinflammatory diseases.
Purpose of the Study:
- To review the incidence of pericarditis in systemic rheumatic diseases.
- To explore the clinical features and underlying mechanisms of idiopathic recurrent pericarditis.
- To outline treatment strategies for acute and idiopathic pericarditis.
Main Methods:
- Literature review on pericarditis frequency in rheumatic diseases.
- Analysis of clinical manifestations and pathophysiology of IRP.
- Summary of current therapeutic guidelines for acute and idiopathic pericarditis.
Main Results:
- Pericarditis is observed in various systemic rheumatic conditions.
- IRP exhibits characteristics aligning with autoinflammatory conditions.
- Established therapeutic algorithms exist for acute and idiopathic pericarditis.
Conclusions:
- Understanding pericarditis in rheumatic diseases is crucial.
- IRP represents a distinct clinical entity with autoinflammatory features.
- Standardized treatment approaches are available for acute and idiopathic pericarditis.
Abstract:
Pericarditis is the term for inflammatory involvement of the pericardium, which can be associated with pericardial effusion and myocardial involvement (perimyocarditis). Pericarditis can be present in the context of systemic inflammatory rheumatic diseases but can also constitute a distinct disease entity. Idiopathic recurrent pericarditis (IRP) describes relapsing conditions of pericarditis with an unknown cause, which show essential common features with autoinflammatory diseases. This article gives an overview of the frequency of pericarditis in systemic rheumatic diseases. Moreover, the clinical manifestations and pathophysiology of IRP are discussed. Finally, the therapeutic algorithms for acute and idiopathic pericarditis are explained.
Related Concept Videos
Pericarditis I: Introduction
Pericarditis II: Clinical Features and Diagnostic Tests
Pericarditis IV: Nursing Management
Pericarditis III: Medical Management
Rheumatic Heart Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

