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Histopathological characteristics and CD163 immunostaining pattern in fibrous papule of the face

Fatma Tokat1, Engin Sezer2, Deniz Duman2

  • 1Department of Pathology, Acıbadem University School of Medicine, Istanbul, Turkey.

Journal of Cutaneous Pathology
|November 20, 2020
PubMed
Abstract

Insights

Inflammatory signs and pagetoid dyskeratosis are common in fibrous papule (FP). CD163 immunostaining aids diagnosis in unusual FP subtypes, highlighting dendritic cell proliferation.

Area of Science:

  • Dermatopathology
  • Histopathology
  • Immunohistochemistry

Background:

  • Fibrous papule (FP) typically shows minimal inflammation.
  • Inflammatory signs like epidermal changes, spongiosis, and dermal inflammation are rarely documented in FP.
  • Pagetoid dyskeratosis is an infrequent finding in FP.

Purpose of the Study:

  • To detail inflammatory parameters in FP.
  • To determine the frequency of pagetoid dyskeratosis in FP.
  • To evaluate CD163 immunohistochemical staining as a diagnostic aid for FP.

Main Methods:

  • Histopathological analysis of 32 biopsy-proven FP cases.
  • Assessment of inflammatory features and pagetoid dyskeratosis.
  • CD163, CD10, and CD34 immunostaining of dermal cells.

Main Results:

  • High prevalence of inflammatory parameters: interface changes (62.5%), spongiosis (96.9%), and dermal inflammation (96.9%).
  • Pagetoid dyskeratosis observed in 25% of cases.
  • Strong, grade 4 CD163 staining in a dendritic pattern in all FP cases, outperforming CD10 and CD34.

Conclusions:

  • Dendritic cell proliferation in FP may indicate an inflammatory response.
  • Pagetoid dyskeratosis is a common, underrecognized feature of FP.
  • CD163 immunostaining is a valuable adjunctive diagnostic tool for atypical FP histopathology.
Keywords:
CD163fibrous papuleinflammationpagetoid dyskeratosis

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