Advanced Lung Cancer Inflammation Index Predicts Outcomes of Patients With Colorectal Cancer After Surgical Resection

Area of Science:

• Oncology
• Biomarkers
• Surgical Outcomes

Background:

• The advanced lung cancer inflammation index (ALCI) is a recognized prognostic biomarker in various malignancies.
• Its prognostic significance in colorectal cancer (CRC) patients post-surgical resection remains under investigation.

Purpose of the Study:

• To evaluate the prognostic value of the ALCI in patients with colorectal cancer.
• To clarify the clinical relevance of the ALCI in predicting outcomes after CRC surgery.

Main Methods:

• Retrospective analysis of prospectively collected data from 298 colorectal cancer patients who underwent surgical resection.
• Evaluation of the correlation between ALCI status and clinicopathological factors, including survival outcomes.

Main Results:

• Low ALCI status significantly correlated with undifferentiated histology, advanced T stage, R1/R2 resection, and distant metastasis.
• Multivariate analysis identified low ALCI as an independent prognostic factor for overall survival (HR=3.21) and disease-free survival (HR=2.13).
• Prognostic value was consistent across sexes and validated in Stage III CRC patients.

Conclusions:

• The advanced lung cancer inflammation index may serve as a valuable prognostic indicator for patients undergoing surgical resection for colorectal cancer.
• Low ALCI status is associated with adverse clinicopathological features and predicts unfavorable survival outcomes in CRC patients.