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Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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Updated: Nov 29, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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The Intersection of Disability and Pregnancy: Risks for Maternal Morbidity and Mortality.

Caroline Signore1, Maurice Davis1, Candace M Tingen1

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Journal of Women'S Health (2002)
|November 20, 2020
PubMed
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Women with disabilities may face increased risks during pregnancy and postpartum care. More research is needed to understand these risks and provide tailored information for healthier pregnancies.

Keywords:
disabilitymaternal healthmaternal mortalitymorbiditypregnancy

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Area of Science:

  • Maternal Health
  • Disability Studies
  • Reproductive Health

Background:

  • An estimated 25% of US women have a disability, with 10-12% of childbearing age affected.
  • Limited data exist on pregnancy, delivery, and postpartum care outcomes for women with disabilities.
  • Existing research shows variable risks for conditions like preeclampsia and infection.

Purpose of the Study:

  • To review conditions contributing to maternal morbidity and mortality in pregnant women with disabilities.
  • To highlight the need for tailored information for patients and providers.
  • To identify research gaps and provide resources for further investigation.

Main Methods:

  • Literature review and synthesis of existing research.
  • Overview of conditions impacting maternal health in this population.
  • Identification of areas requiring further systematic evidence.

Main Results:

  • Pregnancy is possible for women with disabilities, but specific risks vary by condition.
  • There is a critical need for condition-specific information for managing pregnancy and postpartum care.
  • Current evidence is insufficient to guide comprehensive care across diverse disabilities.

Conclusions:

  • Further research is essential to clarify the interaction between specific disabilities and pregnancy.
  • Evidence-based information is needed to reduce risks for mothers and infants.
  • This article provides an overview and resources to advance research in this area.