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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Kuwait
Abdullah Alshukry1, Hamad Ali2,3, Yaseen Ali1
1Department of Otolaryngology & Head and Neck Surgery, Jaber Al-Ahmad Hospital, Ministry of Health, South Surra, Kuwait.
Insights
This study of 417 hospitalized coronavirus disease 2019 (COVID-19) patients in Kuwait found that 39.3% were asymptomatic. Of those admitted to the intensive care unit (ICU), 95.1% developed acute respiratory distress syndrome, with an overall mortality rate of 14.4%.
Area of Science:
- Infectious Diseases
- Pulmonology
- Critical Care Medicine
Background:
- Coronavirus disease 2019 (COVID-19) is a global pandemic.
- Understanding the clinical characteristics and outcomes of hospitalized patients is crucial.
Purpose of the Study:
- To describe the clinical features, complications, and outcomes of COVID-19 patients admitted to a hospital in Kuwait.
- To identify risk factors for intensive care unit (ICU) admission and mortality.
Main Methods:
- Retrospective single-center study of 417 consecutive COVID-19 patients.
- Data collected on demographics, symptoms, comorbidities, ICU admission, complications, and mortality.
- Chest high-resolution computed tomography (HRCT) and laboratory markers analyzed for ICU cases.
Main Results:
- 39.3% of patients were asymptomatic, 41% had mild/moderate symptoms, and 19.7% required ICU admission.
- Common symptoms included fever and dry cough; shortness of breath was prevalent in ICU admissions (75.6%).
- ICU admissions were associated with sepsis (68.3%), acute respiratory distress syndrome (ARDS) (95.1%), heart failure (63.4%), and higher rates of diabetes and hypertension.
- Mortality rate was 14.4%, with a mean age of death of 54.20 years, predominantly in males (90%).
- Chest HRCT in ICU cases showed multifocal ground-glass opacities and consolidation.
- Abnormal laboratory markers related to infection, inflammation, coagulation, cardiac, and kidney function were observed in ICU patients.
Conclusions:
- A significant proportion of hospitalized COVID-19 patients in Kuwait were asymptomatic or had mild symptoms.
- ARDS, sepsis, and heart failure were major complications leading to ICU admission.
- Comorbidities like diabetes and hypertension were more common in severe cases requiring ICU care.
- The study highlights the severity of COVID-19, with a notable mortality rate and specific radiological and laboratory findings in critically ill patients.
Abstract:
This is a retrospective single-center study of 417 consecutive patients with coronavirus disease 2019 (COVID-19) admitted to Jaber Al-Ahmad Hospital in Kuwait between February 24, 2020 and May 24, 2020. In total, 39.3% of patients were asymptomatic, 41% were symptomatic with mild/moderate symptoms, 19.7% were admitted to the intensive care unit (ICU). Most common symptoms in cohort patients were fever (34.3%) and dry cough (32.6%) while shortness in breath was reported in (75.6%) of ICU admissions. Reported complications requiring ICU admission included Sepsis (68.3%), acute respiratory distress syndrome (95.1%) and heart failure (63.4%). ICU patients were more likely to have comorbidities, in comparison to non-ICU patients, including diabetes (35.4% vs 20.3%) and hypertension (40.2% vs 26.9%). Mortality rate of cohort was 14.4% and mean age of death was 54.20 years (± 11.09) and 90% of death cases were males. Chest high-resolution computed tomography for ICU cases reveled multifocal large patchy areas of ground glass opacification mixed with dense consolidation. Cases admitted to ICU showed abnormal levels of markers associated with infection, inflammation, abnormal blood clotting, heart problems and kidney problems. Mean hospital stay for asymptomatic cases was 20.69 days ±8.57 and for mild/moderate cases was 21.4 days ±8.28. Mean stay in ICU to outcome for survivors was 11.95 days ±8.96 and for death cases 13.15 days ±10.02. In this single-center case series of 417 hospitalized COVID-19 patients in Kuwait 39.3% were asymptomatic cases, 41% showed mild/moderate symptoms and 18.7% were admitted to ICU with a mortality rate of 14.4%.
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