Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

4.4K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Routine external aortic compression versus no aortic compression in elective caesarean delivery to reduce blood loss: study protocol of a randomised controlled trial.

BMJ open·2026
Same author

Visual acuity assessments at 5 years in a national cohort (EPIPAGE-2).

Archives of disease in childhood. Fetal and neonatal edition·2026
Same author

Prenatal Air Pollution Exposure During Late Pregnancy Associates With Food Sensitization at 18 Months.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Early Prediction of Outcome Using Lactate Dehydrogenase and Amplitude-Integrated EEG in Transported Newborn Infants with Hypoxic-Ischaemic Encephalopathy.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same author

Developmental Trends in Serum Iron, Transferrin, and Transferrin Saturation From Birth to 12 Months.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same author

Heart rate trends in healthy newborns ≥35+0 weeks' gestation after caesarean delivery with extrauterine placental transfusion and physiology-based cord clamping: a Norwegian observational study (INTACT-3).

BMJ open·2026

Related Experiment Video

Updated: Nov 29, 2025

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
06:34

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

5.3K

Soluble Transferrin Receptor during infancy and reference intervals for the Roche Cobas platform.

Sara Marie Larsson1,2, Andreas Hillarp1, Pia Karlsland Åkeson3

  • 1Department of Clinical Chemistry, Hospital of Halland, Halmstad, Sweden.

International Journal of Laboratory Hematology
|November 20, 2020
PubMed
Summary
This summary is machine-generated.

New reference intervals for soluble transferrin receptor (sTfR) in infants are established. sTfR may improve infant iron status assessment as it is unaffected by inflammation.

Keywords:
acute phase responseinfancyironreference intervalssTfR

More Related Videos

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.2K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K

Related Experiment Videos

Last Updated: Nov 29, 2025

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
06:34

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

5.3K
Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.2K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K

Area of Science:

  • Biochemistry
  • Pediatrics
  • Clinical Diagnostics

Background:

  • Infant iron status assessment is complicated by infections, necessitating reliable biomarkers.
  • The soluble transferrin receptor (sTfR) is a potential biomarker for iron status, minimally affected by acute phase responses.
  • Established reference intervals for sTfR during infancy are lacking.

Purpose of the Study:

  • To establish reference intervals for sTfR in healthy term infants from birth to 12 months.
  • To evaluate the influence of C-reactive protein (CRP) on sTfR measurements in infants.
  • To assess the utility of sTfR as a biomarker for infant iron status.

Main Methods:

  • Quantified sTfR and CRP concentrations in 451 infants at birth, 48-96 hours, 4 months, and 12 months.
  • Established reference intervals using 2.5th and 97.5th percentiles.
  • Analyzed the correlation between sTfR and CRP (>1 mg/L) using Kendall correlation.

Main Results:

  • Provided reference intervals for sTfR across different infant ages (birth to 12 months).
  • Observed no significant sex-based differences in sTfR except at 4 months.
  • Found sTfR did not covary with CRP concentrations >1 mg/L, except for samples taken at 48-96 hours.

Conclusions:

  • This study provides crucial reference intervals for infant sTfR from birth to 12 months.
  • sTfR demonstrates potential as a valuable diagnostic tool for infant iron status.
  • The lack of covariation between sTfR and CRP at most time points supports its use in the presence of inflammation.