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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

Shruti Bhatt1, Marissa S Pioso2, Elyse Anne Olesinski2

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA; Department of Pharmacy, National University of Singapore, Singapore.

Cancer Cell
|November 20, 2020
PubMed

Keywords:
BCL-2BH3 mimeticsBH3 profilingFLT-3MCL-1SMACleukemiamitochondriaprecision cancer medicinevenetoclax

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