Related Experiment Video

Updated: Nov 29, 2025

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

24.6K

Reduction in SLEDAI is associated with improved arterial stiffness in systemic lupus erythematosus

Tian Du1,2, Haiyu Pang3, Faming Ding1

  • 1Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing.

Medicine
|November 21, 2020
PubMed

Insights

Reducing systemic lupus erythematosus disease activity improves arterial stiffness and lipid profiles. Lowering SLEDAI scores in patients with lupus may reduce atherosclerosis risk.

Area of Science:

  • Cardiology
  • Rheumatology
  • Biochemistry

Background:

  • Lipid abnormalities contribute to premature atherosclerosis in Systemic Lupus Erythematosus (SLE) patients.
  • Monitoring SLE disease activity is crucial for managing cardiovascular risk.

Purpose of the Study:

  • To investigate changes in lipid profiles and arterial stiffness in SLE patients with reduced SLE disease activity index (SLEDAI).
  • To assess correlations between inflammation markers, SLEDAI, arterial stiffness, and lipid profiles.

Main Methods:

  • Longitudinal study of 51 female SLE patients with baseline SLEDAI ≥ 6 and >3 reduction at 1-year follow-up.
  • Measured neutrophil-to-lymphocyte ratio (NLR), ESR, hsCRP, TC, LDL-C, HDL-C, TG, and mean brachial-ankle pulse wave velocity (baPWV).
  • Compared baseline and 1-year follow-up measurements, analyzing correlations adjusted for confounders.

Main Results:

  • Significant reductions observed in ESR, mean baPWV, TG, and TC to HDL-C ratio.
  • No significant changes in HDL-C, hsCRP, or NLR.
  • Significant correlations found between reduced ESR and TG, and reduced SLEDAI and mean baPWV.

Conclusions:

  • SLE patients achieving SLEDAI reduction demonstrate improved arterial stiffness.
  • Reducing SLEDAI may mitigate atherosclerosis risk in SLE patients.
  • Further research can explore therapeutic strategies targeting SLEDAI reduction for cardiovascular benefit.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.6K
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.3K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
201
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
189
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
266
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
131
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
178
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
175