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Thyroid dysfunction and cardiovascular events in patients with chronic kidney disease: A protocol of systematic

Tongtong Liu1, Yingjie Guan2, Juan Li1

  • 1Guang'anmen Hospital, China Academy of Chinese Medical Sciences.

Medicine
|November 21, 2020
PubMed

Insights

This systematic review investigates if hypothyroidism independently predicts cardiovascular risk in chronic kidney disease (CKD) patients. Findings will inform clinical management of CKD with hypothyroidism.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiology

Background:

  • Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD) patients.
  • Hypothyroidism is a common complication in CKD patients and is known to increase cardiovascular risk.
  • The independent predictive role of hypothyroidism for cardiovascular risk in CKD patients requires further investigation.

Purpose of the Study:

  • To systematically review and meta-analyze existing studies to determine if hypothyroidism is an independent predictor of cardiovascular risk in patients with CKD.
  • To provide robust evidence on the association between hypothyroidism and cardiovascular outcomes in the CKD population.

Main Methods:

  • A comprehensive literature search will be conducted across multiple databases including PubMed, Embase, Web of Science, CNKI, CBM, and Wanfang.
  • Eligible study designs include cross-sectional, case-control, and cohort studies examining the link between hypothyroidism and cardiovascular risk in CKD patients.
  • Data extraction and quality assessment will be performed independently by two researchers, with data synthesis using STATA and TSA software.

Main Results:

  • The systematic review will evaluate the association by analyzing the incidence of cardiovascular events in CKD individuals with hypothyroidism.
  • Quantification of the risk conferred by hypothyroidism on cardiovascular events in CKD patients will be performed.

Conclusions:

  • This study aims to provide significant evidence regarding the correlation between hypothyroidism and cardiovascular risk in CKD patients.
  • The findings are expected to contribute to improved clinical management and practice for the CKD population, particularly those with co-existing hypothyroidism.
Abstract

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