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Updated: Nov 29, 2025

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

PlGF Immunological Impact during Pregnancy.

Loredana Albonici¹, Monica Benvenuto^1,2, Chiara Focaccetti^1,3

¹Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.

International Journal of Molecular Sciences

|November 21, 2020

Summary

Pregnancy involves immune tolerance to prevent rejection, with placental growth factor (PlGF) crucial for implantation and placental development. Imbalances in PlGF and immune response can lead to pre-eclampsia.

Keywords:

Flt-1/VEGFR1 PlGF immune modulation pregnancy

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Last Updated: Nov 29, 2025

Isolation of Leukocytes from the Human Maternal-fetal Interface

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Published on: May 21, 2015

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Published on: May 21, 2015

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

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Published on: October 14, 2021

Area of Science:

Reproductive Immunology
Maternal-Fetal Medicine
Immunology

Background:

Pregnancy requires maternal immune tolerance to paternal antigens while maintaining anti-infectious defenses.
Early pregnancy involves a balance of inflammation and immune tolerance, crucial for tissue remodeling, angiogenesis, and embryo implantation.
The trophoblast's invasive nature mirrors tumor behavior, necessitating immune privilege and angiogenesis for successful gestation.

Purpose of the Study:

To review the immunomodulatory effects of placental growth factor (PlGF) during pregnancy.
To elucidate PlGF's role in supporting early implantation and placental development via innate and adaptive immune cells.
To highlight the link between PlGF imbalance, altered immune responses, and hypertensive disorders like pre-eclampsia.

Main Methods:

Literature review of current knowledge on PlGF and immune regulation in pregnancy.
Analysis of cytokine and growth factor involvement in pregnancy.
Examination of the relationship between immune response alterations and pre-eclampsia.

Main Results:

Placental growth factor (PlGF) is upregulated during pregnancy and inflammation, playing a key role in immune modulation.
PlGF supports implantation and placental development by influencing innate and adaptive immune cells.
Alterations in immune response and PlGF levels are associated with hypertensive disorders, including pre-eclampsia.

Conclusions:

PlGF is essential for maintaining immune balance during pregnancy, facilitating successful implantation and placental development.
Dysregulation of PlGF and the immune system can precipitate hypertensive conditions such as pre-eclampsia.
Understanding PlGF's immunomodulatory functions is critical for managing pregnancy complications.