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Correlation between HPV-negative cervical lesions and cervical microenvironment.

Jing-Jing Zheng1, Jing-Rui Miao1, Qiang Wu2

  • 1Department of Obstetrics and Gynecology, The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia 010059, China.

Taiwanese Journal of Obstetrics & Gynecology
|November 21, 2020
PubMed
Summary
This summary is machine-generated.

Vaginal micro-ecological imbalance and weakened cervical immunity contribute to cervical lesions, even in high-risk human papillomavirus (HR HPV)-negative cases. Restoring vaginal flora and immune function may prevent lesion progression.

Keywords:
Cervical intraepithelial neoplasiaCervical microenvironmentCervicalsquamous cellcarcinomaVaginal micro-ecology

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Area of Science:

  • Gynecology
  • Microbiology
  • Immunology

Background:

  • Cervical lesions are associated with high-risk human papillomavirus (HR HPV) infection.
  • The role of the vaginal microenvironment in HR HPV-negative cervical lesions requires further investigation.

Purpose of the Study:

  • To explore the relationship between HR HPV-negative cervical lesions and the cervical microenvironment.
  • To identify pathogenic factors contributing to HR HPV-negative cervical lesions.

Main Methods:

  • Vaginal micro-ecological indicators, immune factors (SIgA, IgG, IL-2, IL-10), and infections (HPV, Mycoplasma, Chlamydia) were analyzed in women with and without cervical lesions.
  • Microbial analysis included Gram staining, microscopy, and substrate colorimetry.
  • ELISA and genetic testing were employed for immune factor and infection detection.

Main Results:

  • Cervical lesions correlated with decreased dominant lactobacilli, dysbacteriosis, and altered vaginal flora diversity and concentration.
  • Hydrogen peroxide (H2O2) levels changed with lesion progression, while SNa, LE, GUS, and GADP increased.
  • Immune factor concentrations shifted, with decreased IL-2 and increased IL-10 as lesions progressed; SIgA was significantly lower in patients with lesions.

Conclusions:

  • Vaginal micro-ecological imbalance and weakened local cervical immunity are key factors in cervical lesion development.
  • Regulating vaginal micro-ecology and enhancing immune function may inhibit cervical lesion progression.
  • Biomarkers like Lactobacillus, IL-2, IL-10, and SIgA can guide management and predict outcomes in HPV-positive women.