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Georgina M S Ross¹, Daniel Filippini², Michel W F Nielen³

¹Wageningen Food Safety Research (WFSR), Wageningen University & Research, P.O. Box 230, 6700, AE, Wageningen, the Netherlands.

Analytica Chimica Acta

|November 21, 2020

Summary

This summary is machine-generated.

A new handheld device simplifies food allergen testing by combining sample preparation and analysis on a single chip. This inexpensive immunosensor allows consumers to easily detect allergens like peanut and hazelnut in bakery products.

Keywords:

3D-printing Food allergen testing Lateral flow immunoassay Sample preparation Smartphone-imaging Unibody-lab-on-chip

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Area of Science:

Food Science
Analytical Chemistry
Biotechnology

Background:

Consumer-focused food analysis is hindered by complex sample preparation.
On-site allergen detection requires laboratory skills, limiting accessibility.

Purpose of the Study:

To develop a compact, inexpensive immunosensor for multiplex allergen lateral flow immunosensing.
To integrate sample preparation and on-chip reagent storage for consumer-friendly diagnostics.

Main Methods:

A handheld prototype combining solid-liquid extraction, 3D-sieve filtration, and a 3D-printed unibody lab-on-a-chip (ULOC) microdevice.
On-chip reagent storage for labeled antibodies and buffer, enabling pipette-free dilution.
Smartphone-based detection of hazelnut and peanut allergens in bakery products.

Main Results:

The system achieved homogenization, extraction, filtration, and dilution in under a minute.
Detection of allergens as low as 0.1 ppm in real bakery products.
Demonstrated consumer operability for citizen science applications.

Conclusions:

The novel immunosensor prototype simplifies allergen testing for consumers.
The integrated system paves the way for personalized diagnostics and broader analytical applications.