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Multiscale three-dimensional imaging of the placenta.

Rohan M Lewis1, Jennifer E Pearson-Farr1

  • 1University of Southampton, Faculty of Medicine, UK.

Placenta
|November 21, 2020
PubMed
Summary

Multiscale 3D imaging reveals placental structure and function across various scales. Advanced techniques enhance understanding of placental processes in health and disease.

Keywords:
ConfocalImagingLight-sheet microscopyPlacentaSerial block face scanning electron microscopymicroCt

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Area of Science:

  • Reproductive biology
  • Medical imaging
  • Cell biology

Background:

  • Placental function is complex, involving processes across multiple scales, from centimeters to nanometers.
  • All placental functions, including blood flow and gene expression, are situated within a 3D anatomical framework.
  • Understanding this 3D structure is crucial for comprehending placental function.

Purpose of the Study:

  • To review multiscale three-dimensional (3D) imaging approaches for studying placental structure and function.
  • To highlight how these 3D imaging techniques provide insights into placental processes at different biological scales.
  • To emphasize the importance of 3D imaging in exploring the structure-function relationship of the placenta.

Main Methods:

  • Microcomputed tomography (microCT)
  • Confocal microscopy
  • Super-resolution microscopy
  • Light-sheet microscopy
  • Serial block-face scanning electron microscopy (SBF-SEM)

Main Results:

  • Multiscale 3D imaging allows visualization of placental structures across diverse scales, from macroscopic to nanoscopic.
  • These techniques reveal spatial relationships between placental structures that are not evident in 2D.
  • 3D imaging facilitates the visualization of complex structures crucial for placental function.

Conclusions:

  • Multiscale 3D imaging approaches offer unprecedented insights into placental structure and function.
  • Understanding the 3D architecture is key to exploring the relationship between placental structure and function.
  • These advanced imaging techniques are poised to significantly enhance our knowledge of placental biology in both healthy and diseased states.