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COVID19- clinical presentation and therapeutic considerations

Grace Kenny1, Patrick W Mallon1

  • 1Centre for Experimental Pathogen Host Research, University College Dublin, Ireland; Department of Infectious Diseases, St Vincent's University Hospital, Dublin, Ireland.

Biochemical and Biophysical Research Communications
|November 21, 2020
PubMed

Insights

Developing effective therapies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains challenging due to abnormal host responses and varied disease mechanisms. This review explores current and future therapeutic options for COVID-19, highlighting development hurdles.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Pharmacology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted significant therapeutic challenges.
  • Abnormal host immune responses are a primary driver of severe COVID-19 disease.
  • Understanding the distinct pathogenic mechanisms across COVID-19 stages is crucial for effective treatment.

Purpose of the Study:

  • To review current and potential future therapies for COVID-19.
  • To identify and discuss the challenges in developing effective therapeutic options for pandemic infections.
  • To summarize data on therapeutic strategies against SARS-CoV-2.

Main Methods:

  • Mini-review of existing scientific literature.
  • Synthesis of data on current and emerging COVID-19 therapies.
  • Analysis of pathogenic mechanisms and host response in COVID-19.

Main Results:

  • Few effective therapies have been identified despite extensive research efforts.
  • Therapeutic development is complicated by the diverse pathological processes in COVID-19.
  • Significant challenges persist in creating broadly effective treatments for SARS-CoV-2.

Conclusions:

  • Developing targeted therapies for COVID-19 requires addressing complex host-pathogen interactions.
  • Future research must focus on overcoming the inherent difficulties in pandemic infection therapeutics.
  • Effective treatment strategies for SARS-CoV-2 are still under active investigation and development.
Keywords:
COVID-19Clinical trialsImmunothearpiesSARS-CoV-2Therapeutics

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