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Updated: Nov 29, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
[SARS-CoV-2 infection and ischemic stroke]
Daniel S Marín-Medina1, Angela María Muñoz-Rosero2, Bertha Ligia Bernal-Bastidas2
1Grupo de Investigación NeuroUnal, Unidad de Neurología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia; Grupo de Investigación Applied Neuroscience, Instituto de Epilepsia y Parkinson del Eje Cafetero-Neurocentro S.A., Pereira, Colombia.
Abstract:
The new coronavirus SARS-CoV-2 is causing a huge impact on health, economy, and social dynamics. The world is facing an emerging viral disease for which no specific treatment is available, and many aspects of the clinical behavior of the disease are still unknown, which makes the diagnosis and management a big challenge. Various neurological manifestations have been described and associated with SARS-CoV-2 infection. Stroke occurs in up to 6% of all patients with COVID-19, a figure that becomes significant given the large number of patients diagnosed to date. The clinical characteristics, presentation, evolution, and prognosis of these patients seem to have peculiarities that have not been seen in previous forms of stroke. Every time younger patients are observed, without a medical history, without infectious symptoms, with serious neurological results that pose a challenging and difficult approach. This review synthesizes the information available on the clinical characteristics and the proposals for its management.
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