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Ulcerative colitis with concomitant primary sclerosing cholangitis.
1Medical Department, Hospital Sultanah Bahiyah, Gastroenterology Unit, Kedah, Malaysia. zuraidaamin1@gmail.com.
The Medical Journal of Malaysia
|November 21, 2020
Summary
Primary sclerosing cholangitis (PSC), a liver complication of ulcerative colitis (UC), was diagnosed in a pregnant woman. Ursodeoxycholic acid (UDCA) treatment improved her liver function tests.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Background:
- Primary sclerosing cholangitis (PSC) is a significant hepatobiliary complication frequently observed in patients with ulcerative colitis (UC).
- Concomitant PSC in UC patients increases the risk of rapid disease progression and malignancy, including colon and hepatobiliary cancers.
Observation:
- A 26-year-old pregnant woman with newly diagnosed ulcerative colitis presented with elevated alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT).
- Magnetic resonance cholangiopancreatography (MRCP) revealed characteristic intrahepatic bile duct beading and narrowing, indicative of PSC.
Findings:
- The patient was diagnosed with primary sclerosing cholangitis (PSC) in conjunction with ulcerative colitis (UC).
- Initiation of oral Ursodeoxycholic acid (UDCA) therapy led to a notable improvement in liver function test results within three weeks.
Implications:
- This case highlights the importance of vigilant monitoring for PSC in pregnant UC patients.
- Early diagnosis and treatment with UDCA can effectively manage liver function abnormalities associated with PSC in this population.
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