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Updated: Nov 29, 2025

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Published on: April 1, 2022
Percutaneous deep vein arterialization: An emerging technique for no-option chronic limb-threatening ischemia
Zola N'Dandu1, Jonathan Bonilla1, George M Yousef1
1Department of Cardiology, Ochsner Health System, New Orleans, Louisiana, USA.
Insights
Percutaneous deep vein arterialization (pDVA) offers a limb salvage option for patients with end-stage Chronic Limb-Threatening Ischemia (CLTI) when traditional methods fail. This case demonstrates successful pDVA in a high-risk patient facing amputation.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Regenerative Medicine
Background:
- Chronic limb-threatening ischemia (CLTI) is a severe condition often leading to amputation.
- End-stage CLTI with pedal artery occlusion presents challenges for conventional revascularization.
- Limb salvage is the primary goal in managing CLTI.
Observation:
- A patient with no-option CLTI faced imminent major amputation after failed endovascular attempts.
- The patient had end-stage disease with occluded pedal arteries, lacking suitable targets for bypass.
- Conventional revascularization strategies were unsuccessful.
Findings:
- Percutaneous deep vein arterialization (pDVA) was successfully performed as a last resort.
- The pDVA procedure achieved limb salvage in this high-risk patient.
- This nontraditional technique provided a viable revascularization option.
Implications:
- pDVA may be a crucial technique for limb salvage in complex CLTI cases.
- It offers hope for patients previously deemed untreatable, avoiding amputation.
- Further research into pDVA can expand treatment options for CLTI.
Abstract:
Chronic limb-threatening ischemia (CLTI), with characteristic ischemic rest pain, non-healing ulcers, or gangrene attributable to arterial occlusive disease, requires successful revascularization to minimize tissue loss. End-stage CLTI in particular, with occlusion of the pedal arteries, results in a lack of suitable targets for bypass and can result in failure of endovascular revascularization procedures, leaving no option for treatment other than amputation. With limb salvage as the primary goal, nontraditional revascularization techniques such as percutaneous deep vein arterialization (pDVA) may help minimize incidence of amputation. We present a case of a patient with no-option CLTI, at high risk of amputation who failed conventional endovascular revascularization attempts facing imminent major amputation. The limb was salvaged with a successful pDVA procedure.
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