Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Major Somatic Sensory Pathways

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Muscle Ultrasound Is a Sensitive Outcome Measure in ALS.

Muscle & nerve·2026

Same author

Strategic Amyotrophic Lateral Sclerosis Australia-Systems Genomics Consortium (SALSA-SGC): cohort profile.

BMJ open·2026

Same author

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS.

Annals of clinical and translational neurology·2026

Same author

Monoallelic POLR3A Variants Cause Early-Onset Peripheral Neuropathy.

Annals of neurology·2026

Same author

Application of a Clinical-Electrophysiological Model for Identifying Chronic Inflammatory Demyelinating Polyradiculoneuropathy in an Australian Cohort.

Journal of the peripheral nervous system : JPNS·2026

Same author

Comparison of immunity-boosting regimens for COVID-19 upon initiation of immunosuppressive therapy (CIRCUIT): study protocol for a randomised, controlled clinical trial.

BMJ open·2026

Search research articles

Related Experiment Video

Updated: Nov 29, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Pathophysiological associations of transcallosal dysfunction in ALS.

Mehdi A J van den Bos¹, Mana Higashihara^1,2, Nimeshan Geevasinga¹

¹Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.

European Journal of Neurology

|November 21, 2020

Summary

This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) involves reduced transcallosal inhibition, impacting motor cortex excitability. This dysfunction correlates with faster disease progression and increased disability in ALS patients.

Keywords:

ALS pathophysiology TMS cortical neurophysiology transcallosal inhibition

More Related Videos

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Related Experiment Videos

Last Updated: Nov 29, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Area of Science:

Neuroscience
Neurology
Motor Neuron Diseases

Background:

The corpus callosum's involvement in amyotrophic lateral sclerosis (ALS) is known from neuropathological studies.
Understanding transcallosal function alterations is crucial for ALS pathogenesis.

Purpose of the Study:

To investigate if altered transcallosal function contributes to ALS development and progression.
To correlate transcallosal function changes with functional disability in ALS patients.

Main Methods:

Assessed transcallosal function and motor cortex excitability in 17 ALS patients and healthy controls.
Measured transcallosal inhibition, short interval intracortical facilitation (SICF), and short interval intracortical inhibition (SICI).
Utilized clinical and neurophysiological assessments for patient staging.

Main Results:

ALS patients showed significantly reduced transcallosal inhibition compared to controls.
Cortical hyperexcitability, indicated by reduced SICI and increased SICF, was observed in ALS.
Reduced transcallosal inhibition correlated significantly with faster disease progression and muscle strength decline.

Conclusions:

Transcallosal circuit dysfunction is a key pathophysiological mechanism in ALS.
This dysfunction is linked to increased patient disability and accelerated disease progression.
Therapies targeting transcallosal circuit restoration may benefit ALS treatment.