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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
263
Ischemic Heart Disease: Overview01:17

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

140
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Related Experiment Video

Updated: Nov 29, 2025

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
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Zika & heart: A systematic review.

Cristhian Emmanuel Scatularo1, Oswaldo Andrés Ballesteros1, Clara Saldarriaga2

  • 1Division of Cardiology, Sanatorio de la Trinidad Palermo, Buenos Aires City, Argentina.

Trends in Cardiovascular Medicine
|November 21, 2020
PubMed
Summary

Zika virus infection can cause serious heart problems, including in newborns. Early diagnosis and treatment are crucial, as no specific cure currently exists, emphasizing the need for prevention strategies.

Keywords:
HeartNeglected tropical diseasesZika

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Zika virus infection is prevalent in over 80 tropical countries.
  • While often presenting with mild symptoms like rash and fever, Zika can lead to severe cardiovascular issues such as myocarditis, heart failure, and arrhythmias.
  • Congenital Zika syndrome, resulting from maternal transmission, is linked to cardiac septal defects in newborns.

Purpose of the Study:

  • To highlight the critical importance of early recognition and management of cardiovascular complications associated with Zika virus infection.
  • To underscore the necessity of developing effective public health strategies for Zika virus transmission prevention due to the absence of specific antiviral treatments or vaccines.
  • To introduce the NET-Heart project's initiative in systematically reviewing neglected tropical diseases affecting the heart.

Main Methods:

  • Systematic review of scientific literature on Zika virus and its cardiac manifestations.
  • Analysis of cardiovascular complications in adults and congenital defects in infants.
  • Review of existing public health strategies and proposed diagnostic/treatment algorithms.

Main Results:

  • Zika virus infection is associated with a spectrum of cardiovascular complications, including myocarditis, arrhythmias, and heart failure.
  • Congenital Zika syndrome presents with cardiac septal defects, posing significant risks to newborns.
  • Effective prevention and early intervention are paramount due to the lack of specific treatments.

Conclusions:

  • Prompt identification and management of cardiac issues in Zika virus patients are vital for reducing mortality and morbidity.
  • Public health initiatives focused on preventing Zika virus transmission are essential.
  • The NET-Heart project aims to enhance knowledge and provide diagnostic and treatment guidelines for heart conditions in neglected tropical diseases.