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COVID-19 and Digestive System in Children: A Retrospective Study

Mohammadreza Esmaeili Dooki1, Sanaz Mehrabani1, Hadi Sorkhi1

  • 1Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R. Iran.

Archives of Iranian Medicine
|November 22, 2020
PubMed

Insights

COVID-19 in children rarely causes severe gastrointestinal issues. While some children showed elevated liver enzymes, this did not correlate with increased respiratory problems.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hepatology

Background:

  • COVID-19 infection can present with various symptoms in children.
  • Gastrointestinal (GI) and liver involvement are potential manifestations of viral infections.

Purpose of the Study:

  • To identify gastrointestinal and liver injury presentations in pediatric patients with COVID-19.
  • To analyze the relationship between GI/liver symptoms and respiratory involvement in pediatric COVID-19 cases.

Main Methods:

  • Retrospective study of children with suspected COVID-19 symptoms admitted to Amirkola Children's Hospital.
  • Evaluation of clinical manifestations in digestive and respiratory systems.
  • Assessment of liver function tests, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST).

Main Results:

  • Eighteen children were included in the study.
  • Common symptoms included fever, anorexia, nausea, vomiting, cough, diarrhea, and abdominal pain.
  • Elevated ALT (27.8%) and AST (38.9%) were observed; direct bilirubin was raised in icteric cases. No significant relationship was found between pulmonary lesions and abnormal liver enzymes.

Conclusions:

  • Severe clinical GI symptoms were not observed in pediatric COVID-19 patients.
  • Increased liver enzymes in children with COVID-19 did not correlate with more severe respiratory involvement.
Abstract

Keywords:
COVID – 19Gastrointestinal tractLiverPediatric

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