Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Update on "Cell Therapy" Clinics Offering Treatments of Ocular Conditions Using Direct-To-Consumer Marketing Websites in the U.S.

American journal of ophthalmology·2024

Same author

Nongraft epithelialization after COVID-19 infection in a pediatric penetrating keratoplasty.

Indian journal of ophthalmology·2022

Same author

McCannel Suture Technique Resolves Persistent Dysphotopsia Following Laser Peripheral Iridotomy in Phakic Eyes.

Journal of glaucoma·2021

Same author

Force production of human cytoplasmic dynein is limited by its processivity.

Science advances·2020

Same author

Molecular mechanism of cytoplasmic dynein tension sensing.

Nature communications·2019

Same author

Computational Biomechanical Analysis of Asymmetric Ectasia Risk in Unilateral Post-LASIK Ectasia.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2016

Same journal

Corneal deformation mapping and FE-based strain analysis via digital image correlation: Biomechanical changes after CXL and laser refractive surgery.

Experimental eye research·2026

Same journal

Tanshinone IIA inhibits choroidal neovascularization and restores outer blood-retinal barrier function in Vldlr knockout mice.

Experimental eye research·2026

Same journal

Understanding the ocular accumulation of mefuparib and its N-dealkylation metabolite: Pharmacokinetics, melanin affinity, and cellular disposition.

Experimental eye research·2026

Same journal

Mitochondrial Dysfunction and Diabetic Retinopathy: Research Progress from Pathogenic Mechanisms to Therapeutic Targets.

Experimental eye research·2026

Same journal

Middle-wavelength green ambient light attenuates lens-induced myopia progression and is associated with suppression of the Wnt/β-catenin signaling pathway in guinea pigs.

Experimental eye research·2026

Same journal

Experimental Corneal Alkali Burn Models: Methodological Standards, Biological Outcomes, and Translational Gaps.

Experimental eye research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 29, 2025

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

Published on: April 7, 2014

Corneal neovascularization.

Matthew P Nicholas¹, Naveen Mysore¹

¹Flaum Eye Institute, University of Rochester Medical Center, 210 Crittenden Blvd., Rochester, NY, USA.

Experimental Eye Research

|November 22, 2020

Summary

This summary is machine-generated.

Corneal neovascularization, or new blood vessel growth in the cornea, causes vision loss. This review covers its causes, molecular biology, diagnosis, and treatments for this common eye condition.

Keywords:

Angiogenesis Corneal neovascularization Vascular endothelial growth factor (VEGF)

More Related Videos

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

Published on: August 16, 2014

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

Related Experiment Videos

Last Updated: Nov 29, 2025

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

Published on: April 7, 2014

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

Published on: August 16, 2014

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

Area of Science:

Ophthalmology
Vascular Biology
Regenerative Medicine

Background:

Corneal optical clarity is vital for good vision.
Corneal neovascularization (CNV) is a leading cause of global vision loss, leading to opacification and chronic inflammation.
Factors like infection, inflammation, hypoxia, trauma, degeneration, and transplantation can trigger CNV by disrupting corneal angiogenesis safeguards.

Purpose of the Study:

To summarize the etiopathogenesis of corneal neovascularization.
To discuss the molecular biology of corneal angiogenesis.
To review clinical assessment, diagnostic evaluation, and therapeutic strategies for CNV.

Main Methods:

Literature review and synthesis of existing research on corneal neovascularization.
Analysis of the molecular mechanisms underlying angiogenesis in the cornea.
Evaluation of current and emerging treatment modalities.

Main Results:

CNV results from a breakdown of natural anti-angiogenic factors in the cornea.
The molecular pathways driving angiogenesis in the cornea are complex and involve multiple signaling cascades.
Clinical assessment and diagnosis rely on specialized imaging and examination techniques.

Conclusions:

Understanding the molecular basis of CNV is crucial for developing effective therapies.
Early diagnosis and appropriate management of CNV can help prevent vision loss.
Emerging therapies hold promise for treating corneal neovascularization and restoring visual function.