Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioremediation

Bioremediation

Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessment of Different Niobium-Based Catalytic Systems for 5‑Hydroxymethylfurfural Production from Glucose and Microcrystalline Cellulose.

ACS omega·2026

Same author

Tailored high-cell-density fed-batch cultivation and induction strategies for optimized production of a low-immunogenic L-asparaginase mutant in Escherichia coli.

Enzyme and microbial technology·2026

Same author

Enhancing 2,3-butanediol and acetoin production from brewer's spent grain hemicellulosic hydrolysate through bacterial co-cultivation.

New biotechnology·2025

Same author

Lignocellulosic materials valorization in second generation biorefineries: an opportunity to produce fungal biopigments.

Critical reviews in biotechnology·2024

Same author

Transformation of sugarcane molasses into fructooligosaccharides with enhanced prebiotic activity using whole-cell biocatalysts from Aureobasidium pullulans FRR 5284 and an invertase-deficient Saccharomyces cerevisiae 1403-7A.

Bioresources and bioprocessing·2024

Same author

Tailoring a cellulolytic enzyme cocktail for efficient hydrolysis of mildly pretreated lignocellulosic biomass.

Enzyme and microbial technology·2024

Search research articles

Related Experiment Video

Updated: Nov 29, 2025

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Published on: May 18, 2020

Bioprocess intensification: Cases that (don't) work.

Luuk A M van der Wielen¹, Solange I Mussatto², Jan van Breugel³

¹Bernal Institute, University of Limerick, Ireland; Department of Biotechnology, Delft University of Technology, the Netherlands.

New Biotechnology

|November 22, 2020

Summary

Developing affordable, low-carbon biobased manufacturing requires careful cost and emission analysis. Minimizing operational expenditures (OPEX) is crucial for sustainable bio-economic development, outweighing capital cost reduction strategies.

Keywords:

Bioprocess intensification Integrated biobased manufacturing Techno-Economic assessment Thermodynamic analysis

More Related Videos

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

Operation of a Benchtop Bioreactor

Operation of a Benchtop Bioreactor

Published on: September 12, 2013

Related Experiment Videos

Last Updated: Nov 29, 2025

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Published on: May 18, 2020

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

Operation of a Benchtop Bioreactor

Operation of a Benchtop Bioreactor

Published on: September 12, 2013

Area of Science:

Biotechnology and Biobased Manufacturing
Sustainable Chemical Engineering
Green Chemistry

Background:

Affordable and low-carbon biobased manufacturing is essential for sustainable development.
Process intensification is a strategy to reduce capital costs (CAPEX) but may increase operational costs (OPEX).
Balancing CAPEX and OPEX is critical for the economic and environmental viability of biobased processes.

Purpose of the Study:

To analyze the financial and climate impacts of intensified versus non-intensified biobased manufacturing processes.
To evaluate the trade-offs between capital expenditures (CAPEX) and operational expenditures (OPEX) in biobased production.
To identify key strategies for cost and emission reduction in biobased manufacturing.

Main Methods:

Comparative analysis of CAPEX and OPEX for intensified and non-intensified biobased processes.
Exploration of financial and climate cost drivers associated with process intensification.
Provisional assessment of selected industrial biobased manufacturing case studies.

Main Results:

Process intensification for reducing CAPEX must be weighed against increasing financial and climate costs of driving forces.
A fundamental relationship exists between CAPEX, OPEX, and the overall financial and climatic impact of biobased processes.
Operational expenditure (OPEX) minimization emerged as a particularly important factor for sustainable bio-economic development.

Conclusions:

Sustainable bio-economic development hinges on carefully managing the interplay between CAPEX and OPEX.
Minimizing operational expenditures is a key strategy for achieving both economic affordability and low carbon emissions in biobased manufacturing.
Further research is needed to fully explore the financial and climatic implications of process intensification in various industrial contexts.