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Haplobanking induced pluripotent stem cells for clinical use
Stephen Sullivan1, Paul J Fairchild2, Steven G E Marsh3
1Global Alliance for iPSC Therapies, Jack Copland Centre, Heriot-Watt Research Park, Edinburgh, UK.
Stem Cell Research
|November 22, 2020
Summary
Induced pluripotent stem cells (iPSCs) offer a new path for cell therapies. iPSC haplobanking aims to create immune-matched cell therapies by banking diverse HLA-typed iPSC lines to prevent rejection and reduce immunosuppression.
Area of Science:
- Stem Cell Biology
- Immunology
- Regenerative Medicine
Background:
- Induced pluripotent stem cells (iPSCs) represent a significant advancement in cellular therapeutics.
- Patient-specific and immune-matched allogeneic cell therapies are potential applications of iPSCs.
- Two strategies for immunological compatibility include universal donor iPSCs and iPSC haplobanking.
Purpose of the Study:
- To explore the practical aspects of developing and implementing an iPSC haplobanking strategy.
- To discuss the creation of a haplobank for storing iPSC lines selected for homozygous HLA haplotypes.
- To highlight the potential of HLA-matched iPSC therapies in reducing immune rejection and immunosuppressive drug use.
Main Methods:
- The article discusses the practical considerations for establishing an iPSC haplobanking strategy.
- It involves selecting and banking iPSC lines homozygous for different Human Leukocyte Antigen (HLA) haplotypes.
- The goal is to derive therapeutic products that can be immunologically matched to patient populations.
Main Results:
- iPSC haplobanking involves banking iPSC lines selected for homozygous HLA haplotypes.
- Matching iPSC-derived products to a patient's HLA class I and II molecules can minimize immune rejection.
- This approach aims to reduce the reliance on immunosuppressive medications and their associated risks.
Conclusions:
- iPSC haplobanking offers a promising strategy for generating immunologically compatible cell therapies.
- By banking diverse HLA-homozygous iPSC lines, a haplobank can provide HLA-matched products for a large patient population.
- This approach has the potential to significantly improve the safety and efficacy of cell-based regenerative medicine by mitigating immune rejection and immunosuppression.
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