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A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites

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Andrographolide: A Review of Analytical Methods.

Rashmi Patil¹, Vandana Jain¹

¹Department of Quality Assurance, Oriental College of Pharmacy (Affiliated to University of Mumbai), Sanpada, Navi Mumbai, India.

Journal of Chromatographic Science

|November 22, 2020

Summary

Andrographolide, a natural compound from Andrographis paniculata, shows diverse bioactivities. This review covers analytical methods for detecting andrographolide in various samples, aiding research and quality control.

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Area of Science:

Phytochemistry
Analytical Chemistry
Pharmacology

Background:

Andrographolide is a bicyclic diterpenoid lactone found in Andrographis paniculata.
It exhibits significant bioactivities, including anti-inflammatory, antibacterial, and antineoplastic properties, earning it the name "natural antibiotic".

Purpose of the Study:

To review and consolidate information on analytical methods for andrographolide.
To cover methods applicable to biological samples, pharmaceutical formulations, and plant materials.

Main Methods:

Spectrophotometry
Chemiluminescence
Electroanalytical methods
Chromatography (e.g., HPLC, GC)
Hyphenated techniques (e.g., LC-MS, GC-MS)

Main Results:

A comprehensive overview of diverse analytical techniques for andrographolide quantification is presented.
The review highlights the strengths and limitations of each method for different matrices.

Conclusions:

Accurate and reliable analytical methods are crucial for the study and application of andrographolide.
This review serves as a valuable resource for researchers and quality control professionals working with andrographolide.