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The inhibition effect of natural food supplement active ingredients on TP63 carcinoma cell
1Science Education, Department of Mathematics and Science Education, Education Faculty, Kırıkkale University, 71450, Yahşihan, Kırıkkale, Turkey. akgokalp@gmail.com.
Abstract:
In pancreatic cancer, the activities of inhibitory agents were investigated using docking, since the inhibition of TP63, which plays an important role in the spread of cancer with metastasis, in preventing the proliferation and proliferation of this type of cancer. It has been shown that the active ingredients in some plants used as traditional medicines have an inhibitory effect on this cancer type in preventing growth, reproduction and spread. These computational results guide experimental studies, preventing time and item loss; It is an important study in terms of choosing and using the right active substances.
Insights
This study explores plant-derived compounds to inhibit TP63, a key factor in pancreatic cancer metastasis. Computational docking reveals potential therapeutic agents to block cancer growth and spread.
Area of Science:
- Oncology
- Computational Chemistry
- Pharmacology
Background:
- Pancreatic cancer is a deadly disease with limited treatment options.
- TP63 is implicated in cancer proliferation and metastasis.
- Traditional medicines contain compounds with potential anti-cancer activities.
Purpose of the Study:
- To investigate the inhibitory potential of plant-derived compounds against TP63 in pancreatic cancer.
- To identify effective therapeutic agents for pancreatic cancer treatment.
Main Methods:
- Molecular docking simulations were employed to assess the binding affinity of plant compounds to TP63.
- In silico methods were used to predict the inhibitory activity of selected agents.
Main Results:
- Several plant-derived compounds demonstrated significant inhibitory activity against TP63.
- Computational analysis identified promising candidates for further experimental validation.
Conclusions:
- Plant-derived compounds show potential as novel therapeutic agents for pancreatic cancer.
- In silico drug discovery can accelerate the identification of effective anti-cancer treatments.
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